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BMJ 2010;341:c2701

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Unlike some of the other GLP-1 receptor agonists, this Exenatide injection requires administration twice daily

Warning signs requiring prompt evaluation include: Rectal bleeding or blood in stool Unexplained weight loss (beyond expected medication effect) Persistent change in bowel habits lasting more than a few weeks New-onset abdominal pain that differs from typical GLP-1 side effects Iron-deficiency anemia These symptoms warrant investigation regardless of medication use, as they may indicate various gastrointestinal conditions requiring diagnosis

All three sites are interchangeable in practice, and small absorption differences should not affect your treatment outcomes